Key result
The myosin inhibitor blebbistatin shifted murine skeletal muscle towards a highly quasi-helically ordered configuration distinct from the normal resting state.
Population
Murine skeletal muscle (transgenic mouse models)
Comparison
Blebbistatin (myosin inhibitor) vs Normal resting state
Design
Preclinical
Authors
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No direct clinical relevance; leaves open whether myosin inhibition alters human muscle ultrastructure.
Mouse intact skeletal muscle X-ray preparation can be used to study structural hypotheses, revealing multiple helically ordered configurations for resting crossbridges.
Ma et al. (2018) studied Skeletal muscle physiology. Blebbistatin vs. Normal resting state was evaluated on Myosin head configuration and layer line intensity distribution. The myosin inhibitor blebbistatin shifted murine skeletal muscle towards a highly quasi-helically ordered configuration distinct from the normal resting state.
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