Key result
Growth factors such as EGF, IGF-1, HGF, and VEGF play a critical role in gastric ulcer healing by controlling cell proliferation, migration, re-epithelialization, and angiogenesis.
Why the study?
The risk factors and pathogenesis of gastric ulcer complicated with depression remain unclear, and low immune function and gastrointestinal hormone levels may be significant risk factors.
Serum IgA, IgM, GAS, and CCK can serve as predictive biomarkers for the severity of gastric ulcers complicated with depression, while growth factors play a critical role in the cellular mechanisms of ulcer healing.
BACKGROUND: Gastric ulcer (GU) is a common digestive tract disease, and medical records of GU combined with depression are increasingly common. Currently, the risk factors and pathogenesis of GU complicated with depression remain unclear. Low immune function and gastrointestinal hormone levels may also be significant risk factors. Therefore, this study explored the immune function and gastrointestinal hormone levels in patients with GU combined with depression. AIM: To explore the immune function, gastrointestinal hormone level, and clinical significance of patients with GU combined with depression. METHODS: ratio], and gastrointestinal hormone indices [serum gastrin (GAS), cholecystokinin (CCK), and motilin (MTL) levels] were collected. The basic data of the two groups were compared, and the immune function and gastrointestinal hormone indices were analyzed. Multivariate logistic regression was used to analyze the factors influencing the severity of GU complicated with depression. The receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) were used to analyze the value of the immune function index, gastrointestinal hormone index, and combined index in predicting the severity of GU complicated with depression. The AUC of the ROC curve for serum IgA level predicting GU with depression severity was 0.808 [95% confidence interval (CI): 0.760-0.857], the AUC of the serum IgM level was 0.757 (95%CI: 0.700-0.814), the AUC of the serum GAS level was 0.853 (95%CI: 0.810-0.897), the AUC of the serum CCK level was 0.762 (95%CI: 0.709-0.822), the AUC of immune function (IgA, IgM) and gastrointestinal hormone levels (GAS, CCK) for the prediction of GU with depression severity was 0.958 (95%CI: 0.933-0.976). CONCLUSION: Important factors influencing GU complicated with depression are serum IgA, IgM, GAS, and CCK indicators. They can be used as indicators to predict the severity of GU complicated with depression.
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Yang et al. (2023) conducted a review in Gastric Ulcer. Growth factors (EGF, TGFα, IGF-1, HGF, bFGF, VEGF) was evaluated. Growth factors such as EGF, IGF-1, HGF, and VEGF play a critical role in gastric ulcer healing by controlling cell proliferation, migration, re-epithelialization, and angiogenesis.
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