Antibacterial Activity of Serum After Oral Doses of Triacetyloleandomycin, Erythromycin, Potassium Penicillin v and Penicillin V

Triacetyloleandomycin, in this study, produced antistreptococcal and antistaphylococcal activity in the serum of normal men and in children comparable to that produced by equivalent amounts of the erythromycin preparations used. The better and more rapid absorption of oral doses of potassium penicillin V as compared with acid penicillin V was confirmed. It was also shown that penicillin V, either as the acid or as the potassium salt, produced significantly higher peak levels of antibacterial activity than either erythromycin or triacetyloleandomycin.