Key result
Experimental models of Brugada syndrome, including transgenic mice, canine hearts, and patient-specific iPS-CMs, provide novel insights into the mechanisms and pathophysiology of the disease.
Why the study?
Existing experimental models of Brugada syndrome have limitations, whereas newer patient-specific iPS-CM models offer novel insights into its pathophysiology.
Design
Review
Authors
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Should not alter Brugada management; leaves open clinical translation of model-derived mechanisms.
This review highlights the utility and limitations of various experimental models, particularly emerging patient-specific iPS-CMs, in understanding the mechanisms of Brugada syndrome.
Sendfeld et al. (2019) conducted a review in Brugada syndrome. Experimental models was evaluated. Experimental models of Brugada syndrome, including transgenic mice, canine hearts, and patient-specific iPS-CMs, provide novel insights into the mechanisms and pathophysiology of the disease.
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