Key result
The renin-angiotensin system, particularly through Ang-(1-7) and Mas receptor signaling, reduces Plasmodium parasite invasion and regulates host T-cell immune responses during malaria infection.
Why the study?
Does modulation of the renin-angiotensin system reduce parasite invasion and improve outcomes in malaria infection models?
Does modulation of the renin-angiotensin system reduce parasite invasion and improve outcomes in malaria infection models?
Modulating the renin-angiotensin system to favor Ang-(1-7) over Ang II/AT1R signaling may offer a novel therapeutic approach to reduce parasite burden and inflammation in malaria.
May inform adjunctive malaria therapies; leaves open need for prospective human trials before clinical consideration.
Malaria is a worldwide health problem leading the death of millions of people. The disease is induced by different species of protozoa parasites from the genus Plasmodium. In humans, Plasmodium falciparum is the most dangerous species responsible for severe disease. Despite all efforts to establish the pathogenesis of malaria, it is far from being fully understood. In addition, resistance to existing drugs has developed in several strains and the development of new effective compounds to fight these parasites is a major issue. Recent discoveries indicate the potential role of the renin-angiotensin system (RAS) in malaria infection. Angiotensin receptors have not been described in the parasite genome, however several reports in the literature suggest a direct effect of angiotensin-derived peptides on different aspects of the host-parasite interaction. The aim of this review is to highlight new findings on the involvement of the RAS in parasite development and in the regulation of the host immune response in an attempt to expand our knowledge of the pathogenesis of this disease.
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Silva et al. (2016) conducted a review in Malaria. Renin-angiotensin system (RAS) modulation was evaluated. The renin-angiotensin system, particularly through Ang-(1-7) and Mas receptor signaling, reduces Plasmodium parasite invasion and regulates host T-cell immune responses during malaria infection.
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