In vitro study reveals inverse-power-law motility shifts in 3D co-cultures, indicating stromal-epithelial interactions via OCT fluctuation spectroscopy.
<0.01) correlated with the density of stromal cells in 3D co-culture, respectively. We also show how the hyperspectral data can be visualized using these metrics to observe heterogeneity within organoids. This constitutes a simple and powerful tool for detecting and imaging cellular functional changes with OCT.
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Oldenburg et al. (2015) studied this question.
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