Oxa‐azaspiro Derivatives: a Novel Class of Triple Re‐uptake Inhibitors

Oxa-aza spiro compounds: In silico techniques were successfully employed to predict the rank order of derivatives based on their binding affinities to the monoamine transporters, SERT, NET and DAT. The proposed scaffolds derived from the pharmacophore model were experimentally evaluated in vitro and in vivo. A new class of selective “triple” re-uptake inhibitors was discovered, that may be developed further to give novel antidepressant agents.