Comparison of Propofol with Desflurane for Laparoscopic Sleeve Gastrectomy in Morbidly Obese patients: A Prospective Randomized Trial

Background: Laparoscopic sleeve gastrectomy has become one of the most effective treatment options for adults with severe obesity. However, optimal anesthetic management for laparoscopic sleeve gastrectomy has not been described yet. Methods: In this prospective randomized study, we compared the effects of propofol anesthesia (Group 1) with desflurane anesthesia (Group II) in morbid obese patients for laparoscopic sleeve gastrectomy. We compared postoperative recovery and hemodynamic parameters of the patients. We also investigated the changes in tracheal cuff pressure and peak airway pressure of these obese patients during orogastric tube insertion and peritoneal CO2 insufflation. Results: Eye opening and extubation time were longer in the propofol group than in the desflurane group (p < 0.05). No statistical difference was found between the two groups with respect to recovery scores (p > 0.05). Six patients in Group I and eight patients in Group II had sore throat (p > 0.05). Eight patients in Group I and 12 patients in Group II had postoperative nausea. Only one patient had vomiting in Group I. Peak airway pressure and tracheal cuff pressure of the patients in both of the groups showed gradual increase in values during peritoneal insufflation and after orogastric tube insertion compared with the values at intubation during the procedure (p < 0.05).