Beyond Standard Therapy: Antimicrobial Resistance Patterns and MRSA Prevalence in Pyogenic Infections

Pyogenic infections, characterized by the formation of pus, are marked causes of ailment and lead to prolonged hospital stays. The World Health Organization (WHO) has identified skin and soft tissue infections (SSTI’s) as a serious concern due to their detrimental impact on patient health and increase the total burden of infectious diseases. Multidrug-resistant (MDR) microorganisms have become a significant cause of treatment failures, especially methicillin-resistant Staphylococcus aureus (MRSA). Assessing the microbiological composition of pus specimens obtained in an advanced care center, identifying patterns of antibiotic sensitivity, and estimating the frequency of MRSA are the objectives of this study. All pus specimens including (swabs & aspirates) were treated by worth microbiological techniques including Aerobic culture, Morphology, Gram Staining, Motility, Biochemical tests and antimicrobial susceptibility testing. Culture positive pus samples were found to be 84.6% with higher rate among males 88.2% compared to females 81%. Monomicrobial cultures were 86.7% and 13.3% were polymicrobial cultures. Among monomicrobial, 62.5% were gram positive while 37.5% were gram negative bacteria. Staphylococcus aureus was most frequent among gram positive isolates while P. aeruginosa was most frequent among gram negative rods (GNR). Among S. aureus 22.5% were (MRSA). The rising prevalence of MRSA and multidrug-resistant Gram-negative bacteria revealed here renders standard empirical therapy ineffective. We immediately advocate the creation of a local antibiotic policy based on these findings and the reinforcement of antimicrobial stewardship to guide effective treatment and prevent the emergence of resistance.