Key result
Fomitopsis pinicola extract improves glycemic control, insulin levels, and lipid profiles over diabetic controls.
Reveals that Fomitopsis pinicola ethanol extract lowers blood glucose and restores insulin in diabetic rats, highlighting its therapeutic potential against diabetes.
The antidiabetic effect of different doses of water extract (WE) and ethanol extract (EE) was tested on a high-fat diet and streptozotocin (STZ) induced diabetic rats. Parameters were evaluated with normal control (NC), diabetes mellitus control (DM), and metformin (M) groups. In the experiment, nine groups were used with eight rats in each group and three doses of each WE and EE were used, with low, medium, and high doses. The results revealed that the DM group lost a significant amount of weight, whereas the NC group's weight increased throughout the experiment. After treatment with Fomitopsis pinicola, the EE group's weight increased gradually. Liver, kidney, and pancreas weight decreased after STZ injection and returned to normal in EE treated groups. Fasting blood glucose (FBG) levels were observed to be significantly lower after F. pinicola treatment. Serum insulin levels were also restored to normal after mushroom extracts supplementation. Specifically, STZ-induced hyperglycemia was inhibited by high dose EE administration. The biochemical analysis revealed that high-dose EE treatment increased HDL-C and decreased TC, TG, and LDL-C. Results demonstrated that high-dose EE administration protected the organ tissues from oxidative stress by normalizing the antioxidant levels, and CAT, SOD, and GSH-Px suppressed the lethal effect of MDA. The study concluded that F. pinicola EE at the dose 300 mg/kg has a more hypoglycemic, hyperinsulinemic, antioxidant, and antihyperlipidemic effect than NC, DM, and M, and regulates hyperglycemia by increasing insulin secretion.
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Zahid et al. (2020) studied Streptozotocin-induced diabetes mellitus (n=72). Fomitopsis pinicola water and ethanol extracts vs. Normal control, diabetes mellitus control, and metformin was evaluated on Antidiabetic, antioxidant, and antihyperlipidemic effects (fasting blood glucose, insulin, lipid profile, and oxidative stress markers). Administration of Fomitopsis pinicola ethanol extract at 300 mg/kg exhibited hypoglycemic, hyperinsulinemic, antioxidant, and antihyperlipidemic effects compared to diabetic controls and metformin.
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