Substituted and unsubstituted α,α,α-trifluoroacetophenones were reduced by a chiral NAD(P)H-model (RR-Me2PNPH). Both electron-releasing and -withdrawing substituents give better optical yields than unsubstitued compound. The result has been interpreted in terms of three-step mechanism which involves initial electron-transfer process.
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Ohno et al. (1981) studied this question.
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