Inhaled NO for Preterm Infants — Getting to Yes?

Preterm birth, especially at an extremely low gestational age, is often perilous. Despite improved survival associated with contemporary neonatal intensive care, more than one third of survivors with a birth weight of less than 1250 g have bronchopulmonary dysplasia (also known as chronic lung disease of prematurity), usually defined as a need for supplemental oxygen at 36 weeks of postmenstrual age. At least 10 to 15 percent of these infants also show ultrasonographic evidence of brain injury in the neonatal period. The two conditions often coexist and are associated with impaired neurodevelopment.The majority of infants born at an extremely . . .