Key result
Thiazide diuretics linked to ~65% higher risk of new-onset diabetes in hypertensive patients.
Why the study?
Does the use of thiazide diuretics or non-DHP CCBs increase the risk of new-onset diabetes in hypertensive patients?
Cohort (n=1,001)
No
Does the use of thiazide diuretics or non-DHP CCBs increase the risk of new-onset diabetes in hypertensive patients?
Odds Ratio: 1.65 (95% CI 1.12–2.45)
p-value: p=<0.05
Thiazide diuretics and non-DHP CCBs are associated with an increased risk of new-onset diabetes in Taiwanese patients with hypertension.
Antihypertensive drugs have been linked to new-onset diabetes (NOD); however, data on the effect of these drugs on the development of NOD in hypertensive patients has not been well determined in a clinical setting. The aim was to investigate the association between antihypertensive drugs and NOD in Taiwan. We conducted a retrospective study of hypertensive Taiwanese patients receiving antihypertensive drugs treatment between January 2006 and December 2011. Clinical information and laboratory parameters were collected by reviewing the medical records. We estimated the odds ratios (ORs) of NOD associated with antihypertensive drug use; nondiabetic subjects served as the reference group. A total of 120 NOD cases were identified in 1001 hypertensive patients during the study period. The risk of NOD after adjusting sex, age, baseline characteristics, and lipid profiles was higher among users of thiazide diuretics (OR, 1.65; 95% confidence interval (CI), 1.12-2.45) and nondihydropyridine (non-DHP) calcium channel blockers (CCBs) (OR, 1.96; 95% CI, 1.01-3.75) than among nonusers. Other antihypertensive drug classes were not associated with risk of NOD. Our results show that patients with hypertension who take thiazide diuretics and non-DHP CCBs are at higher risk of developing NOD than those who take other classes of antihypertensive drugs in Taiwan.
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Huang et al. (2012) conducted a cohort in Hypertension without diabetes at baseline (n=1,001). Antihypertensive drugs (specifically thiazide diuretics and nondihydropyridine calcium channel blockers) vs. Nonusers of the respective antihypertensive drug class was evaluated on New-onset diabetes (NOD), defined as the first appearance of a diabetes code (ICD-9 code 250) or antidiabetic prescription in medical records (OR 1.65 (thiazide diuretics); OR 1.96 (non-DHP CCBs), 95% CI 1.12-2.45, p=<0.05). Thiazide diuretics (OR 1.65) and nondihydropyridine calcium channel blockers (OR 1.96) significantly increased the risk of new-onset diabetes in hypertensive patients compared to nonusers.
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