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Multiple fluorescent PET (photoinduced electron transfer) sensors of predictively known analyte binding constants are run in parallel to give a large quasilinear dynamic range. The specific case of proton analytes is demonstrated with four near-optimal sensors to produce a range of ca. 9 pH units. Thus, sets of molecular sensors can be persuaded to respond like ion selective electrodes while maintaining the advantages of nanosize and imaging ability.
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Silva et al. (2007) studied this question.
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