Key result
In patients with accelerated hypertension and renal dysfunction, underlying chronic glomerulonephritis predicted a 4.6-fold increased risk of progression to end-stage renal disease compared to hypertensive nephrosclerosis.
Why the study?
Accelerated hypertension frequently causes acute worsening of renal function with high morbidity and mortality, leading to variable outcomes ranging from partial recovery to rapid end-stage renal disease.
Cohort (n=30)
No
Relative Risk: 4.6
Accelerated hypertension causes permanent renal sequelae, with rapid progression to end-stage renal disease especially in patients with underlying chronic glomerulonephritis.
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Etiology assessment may refine ESRD risk stratification in accelerated hypertension with renal dysfunction; leaves open prospective validation of biopsy-guided care.
Anitha et al. (2020) conducted a cohort in Accelerated hypertension and renal dysfunction (n=30). Chronic glomerulonephritis (CGN) vs. Hypertensive nephrosclerosis (HN) was evaluated on Progression to end-stage renal disease (ESRD) (RR 4.6). In patients with accelerated hypertension and renal dysfunction, underlying chronic glomerulonephritis predicted a 4.6-fold increased risk of progression to end-stage renal disease compared to hypertensive nephrosclerosis.
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