Key result
An increase in the Beighton score was significantly associated with an increased likelihood of pathological findings on the head-up tilt table test (OR 1.44).
Why the study?
Is generalized joint hypermobility associated with autonomic nervous system abnormalities on head-up tilt table testing in patients referred for autonomic testing?
Observational (n=115)
Single-blind
No
Is generalized joint hypermobility associated with autonomic nervous system abnormalities on head-up tilt table testing in patients referred for autonomic testing?
Generalized joint hypermobility is significantly associated with an increased likelihood of autonomic nervous system abnormalities, including orthostatic hypotension, POTS, and reflex syncope, on head-up tilt table testing.
May support hypermobility screening during tilt testing; leaves open causality and need for prospective validation before practice change.
AIM: The aim of this study was to investigate the association of autonomic nervous system abnormalities on head-up tilt table test (HUTT) with generalized joint hypermobility, expressed by Beighton score (BS). METHODS: This was a prospective study that included 115 consecutive patients (91 females; mean age 34.35 ± 14.11) referred either for the HUTT or testing of the cardiovascular autonomic reflexes together with HUTT. Generalized joint hypermobility was evaluated according to the BS system after which HUTT was performed. Clinically significant BS was considered if ≥4. RESULTS: Fifteen patients (15.1%) had BS ≥4. Results of the HUTT were normal in 58 (50.4%) patients and in 57 (49.6%) patient HUTT was abnormal. Fifteen (13.0%) patients fulfilled criteria for orthostatic hypotension, 30 (26.1%) for reflex syncope and 21 (18.3%) for postural orthostatic tachycardia syndrome. Patients with pathological findings on HUTT had significantly higher BS compared to patients with normal HUTT (median 1 vs. 0, p = 0.001). There was a significant association between participants with BS ≥4 and pathological HUTT (χ[1] = 6.392, p = 0.011). Results of the multivariate regression analysis revealed that increase in the BS is associated with the increased likelihood of HUTT pathology (Exp[B] 1.44, 95% CI 1.084-1.922, p = 0.012), while increase in age is associated with lower risk of HUTT pathology (Exp[B] 0.968, 95% CI 0.939-0.998, p = 0.036). CONCLUSION: There is an association between autonomic nervous system abnormalities on HUTT test and generalized joint hypermobility.
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Adamec et al. (2018) conducted an observational in Suspected autonomic nervous system disorders (n=115). Generalized joint hypermobility (Beighton score) vs. Normal Beighton score was evaluated on Pathological findings on head-up tilt table test (HUTT) (OR 1.44, 95% CI 1.084-1.922, p=0.012). An increase in the Beighton score was significantly associated with an increased likelihood of pathological findings on the head-up tilt table test (OR 1.44).
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