What question did this study set out to answer?

To determine how the bacterial quorum-sensing molecule N-(3-oxo-dodecanoyl) homoserine lactone (C12) modulates mammalian NF-κB signaling and innate immune defense.

June 19, 2008Science

Modulation of Gene Expression via Disruption of NF-κB Signaling by a Bacterial Small Molecule

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Authors

VKVladimir V. KravchenkoScripps Research Institute GKGunnar F. KaufmannTherapeutics Clinical Research JMJohn C. MathisonScripps Research Institute

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Implication

Experimental study reveals inhibition of NF-κB-driven inflammatory gene expression by bacterial C12 in mammalian cells, suggesting a mechanism for persistent Pseudomonas aeruginosa infections.

Key Points

To determine how the bacterial quorum-sensing molecule N-(3-oxo-dodecanoyl) homoserine lactone (C12) modulates mammalian NF-κB signaling and innate immune defense.
Evaluated the impact of bacterial N-(3-oxo-dodecanoyl) homoserine lactone (C12) on mammalian cell signaling.
Assessed stimulus-mediated activation of the NF-κB transcription factor and measured the downstream expression of NF-κB-responsive immune genes.
Bacterial C12 selectively impaired the regulation and function of NF-κB in activated mammalian cells.
Treatment specifically repressed the stimulus-mediated induction of host genes encoding key inflammatory cytokines and regulatory immune proteins.

Cite This Study

Kravchenko et al. (2008) studied this question.

synapsesocial.com/papers/6a7072cd31a3df824328b4f1 https://doi.org/10.1126/science.1156499

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Implication

Experimental study reveals inhibition of NF-κB-driven inflammatory gene expression by bacterial C12 in mammalian cells, suggesting a mechanism for persistent Pseudomonas aeruginosa infections.

Modulation of Gene Expression via Disruption of NF-κB Signaling by a Bacterial Small Molecule

Discussion

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Implication

Key Points

Cite This Study

Modulation of Gene Expression via Disruption of NF-κB Signaling by a Bacterial Small Molecule

Discussion

Member takes

Implication

Key Points

Cite This Study

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