Animal Models of Antenatal Corticosteroids: Clinical Implications

Alan H. Jobe

doi:10.1097/00003081-200303000-00021

March 1, 2003Clinical Obstetrics & Gynecology

Animal Models of Antenatal Corticosteroids: Clinical Implications

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Key Points

To review preclinical findings from animal models investigating antenatal corticosteroid therapy and translate these physiological insights into optimized clinical practices for preterm delivery.
Synthesis of physiological and pharmacological data from diverse animal models (including sheep, rabbits, and rodents) exposed to antenatal corticosteroids.
Evaluation of pulmonary and extrapulmonary responses across varying drug types, dosages, gestational ages, and administration regimens.
Antenatal corticosteroid exposure accelerates fetal lung maturation, enhances surfactant production, and improves structural compliance across multiple mammalian models.
Repeated or excessive maternal dosing schedules show diminishing pulmonary returns while increasing risks of fetal growth restriction and altered neurodevelopment.
Translational model data indicate that lower, single-course drug exposures achieve significant respiratory benefit while minimizing potential organ system toxicities.

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Implication

Review examines translational findings from animal models evaluating antenatal corticosteroids, highlighting therapeutic dosing strategies for fetal lung maturation.

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Alan H. Jobe (2003) studied this question.

synapsesocial.com/papers/6a7074d987f921057127b160 https://doi.org/10.1097/00003081-200303000-00021

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Animal Models of Antenatal Corticosteroids: Clinical Implications

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Animal Models of Antenatal Corticosteroids: Clinical Implications

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