Case Scenario: Anesthesia for Maternal-Fetal Surgery

FETAL anomalies such as giant neck masses can result in perinatal death or hypoxia and anoxic brain injury due to inability to secure an airway in a timely fashion after delivery. Modern technology, ultrasound, and ultrafast magnetic resonance imaging have enabled intrauterine diagnosis and fetal interventions as a mode of therapy, thereby giving such affected fetuses a chance at survival.Initially, the Ex Utero Intrapartum Therapy (EXIT) procedure was exclusively performed in large tertiary children's hospitals because of the easy availability of pediatric practitioners who can adequately manage the baby-related issues. These hospitals are often in close proximity to or affiliated with maternal obstetric units and involve a multidisciplinary team approach to provide care for both mother and baby. However, these types of procedures are increasingly being performed in diverse hospital settings1; therefore, adequate knowledge about the related intricacies of these cases is warranted.We present the case of a mother carrying a fetus of 37 weeks' gestation with a giant cervical teratoma who underwent the EXIT procedure for fetal airway access. This discussion will focus on the multiple management issues and concerns to be contemplated before embarking on the care of a pregnant mother whose child may need surgery shortly before delivery to ensure neonatal survival.A 35-yr-old healthy, uniparous woman, gravida 2, was referred to our institution's fetal center at 21 weeks' gestation after diagnosis of a giant neck mass with associated moderate polyhydramnios on a routine obstetric ultrasound examination. Fetal magnetic resonance imaging revealed findings consistent with a cervical teratoma and significant airway compromise (fig. 1). Given the degree of airway compromise and distortion of the fetus' anatomy, a multidisciplinary meeting that included anesthesiologists, pediatric surgeons, maternal-fetal medicine specialists, obstetricians, neonatologists, cardiologists, operating room nurses, and labor and delivery room nurses was organized to discuss the fetal anomaly and management approach to delivery of the fetus. Conventional delivery followed by airway maneuvers to intubate the trachea or place a tracheostomy after delivery were thought to be the least favorable options for management given the gross anatomic distortion and potential for hypoxia associated with prolonged attempts at intubation. The EXIT procedure offered the ability to maintain neonatal oxygenation via placental support while trying different approaches to secure a definitive airway, and therefore seemed most favorable after reviewing the fetus' anatomy. Once the plan was concluded by the specialties involved, the family was invited to the meeting for an update on the deliberations and concerns and also to meet members of the team. The questions the family had were also addressed at this time, and appropriate counseling was given. The patient was to be monitored until the fetus was closer to term, at which time the EXIT procedure would be performed. It was also emphasized at this meeting that maternal safety was most important, and the procedure would be aborted if the parturient's health appeared to be at risk at any time.Originally designed to allow removal of tracheal clips that were placed in utero to treat fetuses with severe congenital diaphragmatic hernia, the EXIT procedure has expanded to include indications for not only airway compromise, but also other fetal anomalies in which neonatal resuscitation and survival could be improved with life-saving fetal surgery during placental support.2–4While uteroplacental support is maintained, the baby is partially delivered (head and part of upper torso) and procedures critical for the baby's survival are performed. These may include direct visual laryngoscopy, bronchoscopy, tracheal intubation, tracheostomy, tumor decompression and resection, or placement on extracorporeal membranous oxygenation.4Current indications for the EXIT procedure include large fetal neck masses, which distort the airway anatomy and result in difficult laryngoscopy; large lung or mediastinal tumors, which can result in cardiac compression and arrest upon institution of positive pressure ventilation and are therefore managed with thoracic decompression via thoracotomy before delivery; severe congenital diaphragmatic hernia requiring extracorporeal membrane oxygenation; and congenital high-airway obstruction syndrome such as laryngeal atresia.5Recently, the EXIT procedure and creation of a tracheostomy in the EXIT-to-airway procedure has been performed in fetuses with severe retrognathia or micrognathia with a jaw index of less than the fifth percentile with associated polyhydramnios6(table 1).In addition to routine volatile anesthetic concentrations for maintenance of anesthesia in the mother, an increase in the inspired concentration of volatile anesthetic, up to two to three times the minimal anesthetic concentration, is required during the EXIT procedure to provide maximum uterine relaxation.This is accomplished with the maintenance of maternal blood pressure within 20% of baseline values. Intermittent bolus administration of vasoactive agents such as ephedrine or phenylephrine or a phenylephrine infusion is frequently used during the procedure to counteract the decreased systemic vascular resistance that occurs due to the high volatile agent concentration.Historically, ephedrine had been considered the gold standard for the treatment of hypotension in obstetric anesthesia due to its good safety record, familiarity,7and preservation of uteroplacental blood flow, which was initially demonstrated in animal studies.8The use of pure α-agonists such as phenylephrine had been previously discouraged because of concerns about decreased uteroplacental blood flow.9However, recent evidence shows that ephedrine crosses the placenta to a greater extent than phenylephrine and also undergoes slower metabolism and redistribution in the fetal circulation.10The resulting β stimulation in the fetus is thought to be responsible for the increased incidence of neonatal acidosis observed with its use.10,11In addition, a meta-analysis of studies comparing ephedrine and phenylephrine did not provide any evidence to suggest that phenylephrine decreased uterine blood flow.12Therefore, ephedrine is no longer considered to be preferred over phenylephrine, and both agents are now considered the vasopressors of choice for the treatment of hypotension in obstetric anesthesia.7,12Although volatile anesthetics administered to a mother may cross to the fetus,13supplemental intraoperative anesthetics, especially muscle relaxants and opioids, may be required for the fetus once direct access is obtained.14The goal of the cesarean section is prompt access to and evacuation of the uterine cavity while maintaining uterine tone and minimizing fetal sedation.5In contrast, uterine relaxation is the goal during the EXIT procedure, allowing prolonged intrauterine access to the fetus. The high concentration of anesthetic gas required for uterine relaxation decreases uterine vascular tone and increases the risk for maternal blood loss.15Other differences are itemized in table 2.A thorough medical history must be taken and complete physical examination performed in the mother. Significant cardiac or pulmonary coexisting diseases may exclude the mother from being an ideal candidate for the EXIT.16Polyhydramnios is a common finding in fetuses in whom the trachea and esophagus are compressed by a neck mass; therefore, a detailed obstetric history including the number of amnioreductions, volume withdrawn, and presence of uterine contractions at the time of reduction should be obtained. Massive polyhydramnios can lead to premature labor requiring amnioreduction and/or tocolytic therapy. Tocolytic therapy can affect anesthetic management during the EXIT procedure.16Magnesium sulfate, used for tocolysis, has several additional effects that include increasing the patient's sensitivity to both depolarizing and nondepolarizing muscle relaxants and depression of the central nervous system, and at toxic concentrations it can lead to pulmonary edema, respiratory paralysis, myocardial depression, and cardiac arrest.The physiology of pregnancy itself, including concerns for delayed gastric emptying, should be considered, with adequate precautions taken by administering preoperative sodium citrate and citric acid, a histamine-2 antagonist, and metoclopramide.17,18Amniocentesis can rule out the presence of major underlying chromosomal abnormalities. In addition, fetal imaging including echocardiography is critical to assess ventricular function and the development of heart failure. Heart failure in the fetus may present as hydrops fetalis (accumulation of fluid in one or more fluid cavities, such as the scalp, subcutaneous tissue, pleura, pericardium, or abdomen). Cervical teratomas or congenital cystic adenoid malformations may be associated with hydrops, and this worsens the prognosis of the fetus. The fetal weight is estimated by ultrasound and is used for calculation of any intravenous drugs administered intraoperatively.Large-bore intravenous access and an arterial line in addition to routine monitors are indicated. The patient is positioned with left uterine displacement in order to avoid aortocaval compression. Blood products for both the mother and baby should be in the room, ready for administration.Preoxygenation followed by rapid sequence intubation with either propofol or thiopental, fentanyl, and succinylcholine or rocuronium is performed in order to secure the mother's airway. After tracheal intubation, an ultrasound of the fetus is repeated to confirm fetal well-being and to verify position.High-volatile anesthetic concentrations required to provide adequate uterine relaxation for fetal manipulation result in hypotension. However, normotension is necessary to maintain adequate uteroplacental perfusion; therefore, intermittent administration of vasoactive drugs such as ephedrine is imperative. Infusions of phenylephrine are also useful in maintaining uteroplacental perfusion. Desflurane, isoflurane, or sevoflurane may be used for maintenance of anesthesia.The technique previously described is the anesthetic management used for most EXIT procedures. However, other anesthetic regimens that have their own special considerations and limitations have been described.A recent retrospective study by Boat et al. 19found that early institution of high concentrations of volatile agents for long periods of time before hysterotomy was performed resulted in the development of intraoperative fetal bradycardia, especially when desflurane was used as the maintenance agent. Based on their findings, the authors of this study suggest the utilization of supplemental intravenous anesthesia with propofol and remifentanil until just before the hysterotomy incision is made, at which point high volatile anesthetic concentrations are used to achieve the desired uterine relaxation.19Neuraxial anesthesia has been administered as an alternative to general anesthesia for the EXIT procedure with an accompanying infusion of nitroglycerin to achieve uterine relaxation.20,21This can be used in parturients in whom volatile anesthetics are contraindicated. The myometrial relaxation effect of nitroglycerin, however, may not be easily titrated in comparison with volatile anesthetics, and its use may be associated with hypotension, reflex tachycardia, tachyphylaxis, methemoglobinemia, and headaches in the awake patient. The most appropriate anesthetic regimen should be individualized for each patient.The anesthesiologist dedicated to the baby's care ensures there is a separate pulse oximeter monitor, labeled specifically for intraoperative monitoring of fetal oxygen saturations during the EXIT procedure in the mother's operating room. This anesthesiologist is also responsible for preparing a separate, adjacent room specifically for the newborn baby. This second operating room may become necessary if additional surgery is required on the fetus after separation from the mother; for example, if immediate resection of the neck mass is required. Both operating rooms should be warmed to 80°F just before delivery of the baby to ensure normothermia. In addition, the infant resuscitation area (or adjacent operating room) is equipped with a radiant warmer and/or forced air warming blanket.Before hysterotomy, continuous fetal monitoring can be provided by the cardiologist via echocardiography with precise information on the heart rate, cardiac filling, and contractility. Once access to a fetal extremity is obtained, a pulse oximeter probe is applied to encircle the hand, and information on oxygen saturation and heart rate can be obtained and recorded. Interference from excessive ambient light may necessitate covering the pulse oximeter probe with foil or towels. Initial fetal pulse oximeter readings usually range between 60–70% and will rise as the fetus receives supplemental oxygen following intubation.The required equipment should be obtained and placed on a sterile table in the mother's room before the EXIT procedure (table 3).Intravenous catheter placement in the fetus, while occasionally challenging due to the fetus being covered in vernix, is helpful as fluid administration (albumin or lactated Ringer's solution) may be necessary if the cervical mass resection actually begins on the mother's sterile field.In preparation for care of the newborn baby, the adjacent room is equipped with an intravenous fluid warmer and arterial line transducer, and drugs are prepared based on estimated birth weight.The EXIT procedure was scheduled for a date at which the mother was 35 5/7 weeks' gestation in order to preempt premature labor. On the day of surgery, following adequate preoxygenation, the mother underwent rapid sequence induction and easy tracheal intubation. An additional peripheral intravenous catheter was placed as well as an arterial line for hemodynamic monitoring. The concentration of sevoflurane was gradually increased to 5.5%, at which point adequate uterine relaxation was confirmed by manual palpation after laparotomy. Hysterotomy was performed with a uterine stapling device (U.S. Surgical Corporation, Norwalk, CT). Continuous irrigation of warm lactated Ringer's solution into the uterus was instituted and the fetus' left upper extremity was exposed in order to administer a combination of intramuscular fentanyl, pancuronium, and atropine.The anesthesiologist dedicated to the baby's care placed a pulse oximeter probe on the left hand of the fetus as well as a 24-gauge peripheral intravenous catheter. The catheter placement was easily accomplished because the baby was near term and had adequate peripheral veins.After placement of the pulse oximeter probe and intravenous catheter, the fetal head, neck, and shoulders were delivered, and the head was positioned for direct visual laryngoscopy. Laryngoscopy revealed a grade 4 view and inability to pass the endotracheal tube. Subsequent bronchoscopy performed by the surgeons allowed for successful placement of the endotracheal tube through the distorted airway. Adequate endotracheal tube placement and ventilation was confirmed with a colorimetric end-tidal carbon dioxide detector and fetal chest auscultation, after which the umbilical cord was clamped, and the baby was transferred to the neonatal intensive care unit. The mother received 20 units of oxytocin in a lactated Ringer's solution infusion, which was sufficient to return the uterine tone to normal. The mother was extubated uneventfully and transferred to the recovery room.The baby subsequently underwent appropriate imaging studies and evaluation of the neck mass within the next few days in order to delineate vascular structures, and was returned to the operating room 4 days after delivery for successful resection of the neck mass.Maternal hemorrhage is a real concern in these patients considering the amount of uterine relaxation required for surgery. The staples applied during hysterotomy prevent severe bleeding but an inappropriately applied or loose staple could result in massive bleeding. Hence, adequate preparations should be made for possible intraoperative transfusion, and cross-matched blood should be readily available. The blood bank should be notified that more units may be necessary. Uterotonic agents including oxytocin, methylergonovine, carboprost tromethamine, and misopristol should be available to induce uterine contraction following delivery.Anesthesia for maternal-fetal surgery, in particular the EXIT procedure, is a critical part of the operation. It requires particular attention to detail and coordination between the surgeons and the anesthesiologists. Effective uterine relaxation is crucial to maintaining uteroplacental flow for the duration of the procedure. This is best monitored by manual palpation on the operating field. The adequacy of uterine relaxation is communicated to the anesthesiologist. Furthermore, restoration of uterine tone at the conclusion of the procedure is imperative to prevent excessive bleeding from the placental bed. The surgeons and anesthesiologists must to the duration of the procedure and the of reduction of volatile anesthetic concentration to allow for uterine This is just before the baby is ready to be from the mother. increase in uterine tone occurs uteroplacental flow may be it occurs excessive bleeding may duration of the fetal procedure may on the of the airway anatomy. The procedure may be if a direct or bronchoscopy is that is required to access the airway. a tracheostomy or resection of the neck mass may be required to the of the trachea when access is with the anesthesiologists during these maneuvers is Once access to the airway is obtained and the baby is being the anesthesiologist to the baby over the airway while the surgeons with umbilical vascular access as have that umbilical vascular access on the is because the are The umbilical cord is clamped, and the baby is from the mother and to the resuscitation or to an adjacent operating room for surgery if indicated. the baby at this point requires both the pediatric and the anesthesiologist to ensure the critical airway secure during fetal surgery is a multidisciplinary that requires a team of and nurses and team and utilization of the EXIT procedure to now have who that were previously considered the use of placental has provided in obstetric it should be that it requires a multidisciplinary approach and of fetal surgery, and is for patient must be given to the of delivery. The EXIT procedure is performed before the of labor. The goal is to the pregnancy close to term to the of However, delivery is often because of the of labor or the development of maternal and/or fetal is performed in the immediate preoperative to confirm and placental In most the uterine is of sufficient to a uterine In cases of large masses, or difficult fetal a uterine incision may be required. The of a incision should be with the patient during the preoperative because it increases the risk of with It should also be with the the because uterine are associated with increased blood with uterine in both EXIT procedures as well as cesarean of maternal hemorrhage requires coordination between the anesthesiologist and the After the concentration of the anesthetic is decreased and are The placenta should be allowed to separate and as uterine tone manipulation of the placenta before this point increases the risk for the number of EXIT procedures performed is several case have been in the The case is by et al. in in which EXIT procedures were performed at the of between and patients underwent the EXIT procedure for of tracheal performed for congenital diaphragmatic hernia, in patients with neck masses, and two were in patients with congenital high airway obstruction The second case was by et al. from the of in which patients underwent the EXIT procedure between and this retrospective patients underwent the EXIT procedure for a neck for of tracheal for congenital cystic for congenital high airway obstruction and patient each for extracorporeal membrane pulmonary and as a to separation for these of large from fetal treatment the EXIT procedure has been increasingly performed in diverse hospital indications for the EXIT obstruction is a which if before delivery has a of can be as or obstruction compression by a cervical or a vascular compression is of the congenital high airway obstruction to this case the incidence of teratomas is between in and in with both affected teratomas are that of pediatric usually have and cystic diagnosis is because can the airway. airway compromise occurs in of with large cervical with is if an airway can be at time of delivery. Cervical teratomas may also be associated with lung and compromise, the resulting in heart is a common associated finding because of as a result of its mass The findings of polyhydramnios and a large neck mass suggest airway one study by et an airway was in of fetuses with head and neck masses the EXIT procedure with an survival rate of effect of anesthetic agents on the brain is a concern at this of The EXIT procedure is and information is being about the possible effects of these of the high concentration of agents received in the few of or cystic common for the EXIT procedure, are often after with multiple of and of these a separate evidence from animal studies shows that anesthetic drugs given to an brain and this evidence is and in is difficult to the anesthesia or the underlying is the that to who have the EXIT procedure are being followed for but it is early to any the effect of if on these This is an area of