Key result
Cardiopoietic priming of the endoderm with TNFalpha yielded a secretome network that potentiated embryonic stem cell cardiac commitment and sarcomerogenesis.
Proteomic mapping of the TNFalpha-primed endodermal secretome reveals a systems biology framework for guiding embryonic stem cell cardiopoiesis.
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Supports TNFα-primed secretome exploration in stem cell models; hypothesis-generating for human cardiac regeneration.
Arrell et al. (2007) studied Stem cell cardiopoiesis. TNFalpha-primed endodermal secretome vs. Unprimed endodermal secretome was evaluated on Cardiac commitment and sarcomerogenesis. Cardiopoietic priming of the endoderm with TNFalpha yielded a secretome network that potentiated embryonic stem cell cardiac commitment and sarcomerogenesis.
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