Why the study?
Do potassium channel openers (pinacidil and lemakalim) differentially affect action potential configurations and outward currents in atrial and ventricular myocytes from rabbits and guinea pigs?
Do potassium channel openers (pinacidil and lemakalim) differentially affect action potential configurations and outward currents in atrial and ventricular myocytes from rabbits and guinea pigs?
Potassium channel openers have species- and tissue-specific electrophysiological effects that may contribute to arrhythmogenesis.
No takes yet. Share an insight, caveat, or question.
Species- and chamber-specific PCO effects on repolarization are hypothesis-generating; clinical relevance for arrhythmogenesis remains untested.
Ogbaghebriel et al. (1995) studied this question.