microRNA—Does it Presage the Malignant Change of Oral Potentially Malignant Disorders: A Systematic Review

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Aim: The aim of this systematic review is to uncover the role of microRNAs (miRNAs) in foreseeing malignant progression in oral potentially malignant disorders (OPMD) as the need for an effective yet noninvasive independent biomarker for malignancy is the need of the hour.In recent times, numerous miRNAs have been investigated for their role.Thus, a deduction about the most effective one is needed. Materials and methods:The article search for this systematic review was done using PubMed database, proceeded to adapt preferred reporting items for systematic reviews and meta-analyses (PRISMA) and population, intervention, control, and outcomes (PICO) guidelines.Followed by an assessment of bias and quality in the included articles.Results: As a result of the search strategy, 19 articles were selected.As a result, various miRNAs and their regulation were analyzed.Conclusion: microRNAs were allied with the progression of OPMD into malignancy and also in predicting the progression and prognosis of malignant lesions.Thus, they can be used as a noninvasive independent biomarker for OPMD screening and assessing malignant lesions status.