Hyperimmune serum produced in host mice against allogeneic tumor antigens inhibited and enhanced tumor growth. Fractionation of the antiserum by column chromatography established that immunoglobulin M was primarily responsible for inhibition and immunoglobulin G γ2 for enhancement. Since only one class of immunoglobulin can cause enhancement, mere blocking of the immune response at the peripheral tumor-cell level was rejected in favor of a more central feedback mechanism of control. The functions of distinctive immunoglobulin classes are considered in relation to alloimmune rejection and in the regulation of the overall immune response.
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Takasugi et al. (1969) studied this question.