A mathematical model for the kinetics of the acetone‐butanol fermentation by Clostridium acetobutylicum was developed reflecting the biochemical pathway and culture behavior. Steady‐state concentration of the process parameters in a cell‐retention (CR) fermentation were predicted by computer process simulation. It was established that the product concentrations are independent of the dilution rate ((D F ), whereas the accumulated biomass concentration increased linearly with respect to the dilution rate. The predicted effect of the glucose feed concentration (S o ) on steady‐state concentrations of the process parameters showed that for values of S o greater than 52.0 g/L the CR fermentor cannot attain a steady‐state.
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Mulchandani et al. (1986) studied this question.
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