Squamous cell carcinomas of the respiratory tract were induced in (C57BL × C3H)F1 (BC3F1) and DBA/2 mice by repeated intratracheal injections of 3-methylcholanthrene (MCA). The tumors showed frank invasion and metastasis and were readily transplantable to isogenic recipients. In BC3F1 mice given 6 weekly injections of 0.5 mg MCA, a tumor incidence of 86% with an induction time of 10–28 weeks was observed. Only 3 of 50 DBA/2 mice have developed squamous cell carcinomas at 7 months, after 4 weekly injections of 0.5 mg MCA. The exact origin of the observed respiratory tract carcinomas still needs to be determined.
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Nettesheim et al. (1971) studied this question.