Key result
A functional coculture of human-induced pluripotent stem cell-derived sympathetic neurons and cardiomyocytes was successfully established to demonstrate electrophysiological function.
This study establishes a functional coculture model of human iPSC-derived sympathetic neurons and cardiomyocytes, useful for studying electrophysiological interactions.
Enables mechanistic studies of sympathetic-cardiac interactions in human cells; extends iPSC models but leaves open clinical translation.
We present data on a functional coculture between human-induced pluripotent stem cell-derived sympathetic neurons and cardiomyocytes. Moreover, this study adds significantly to the available data on the electrophysiological function of human-induced pluripotent stem cell-derived sympathetic neurons.
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Winbo et al. (2020) studied this question. A functional coculture of human-induced pluripotent stem cell-derived sympathetic neurons and cardiomyocytes was successfully established to demonstrate electrophysiological function.
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