Oxygen, oxygen, everywhere! Poor sensitivity has hindered the development of solid-state 17O NMR spectroscopy as a practical technique for the structural elucidation of protein complexes. However, this has now changed and it has been demonstrated that multinuclear 17O, 27Al, 13C NMR parameters can be used to aid structural refinement for a protein-bound ligand molecule (see picture).
No takes yet. Share an insight, caveat, or question.
Zhu et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: