January 1, 2000Cytogenetic and Genome Research

Cloning, characterization, and physical mapping of the canine Prop-1 gene (PROP1): exclusion as a candidate for combined pituitary hormone deficiency in German shepherd dogs

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Population

German shepherd dogs with combined pituitary hormone deficiency (CPHD) / dwarfism

Design

Preclinical

Authors

ILIrma S Lantinga‐van LeeuwenLeiden University HKH.S. KooistraUtrecht University JMJan A. MolUtrecht University

Discussion

Member takes

Implication

PROP1 excluded in canine CPHD; leaves open other loci and supports this as a novel spontaneous hypopituitarism model.

Structured PICO

Population

German shepherd dogs with combined pituitary hormone deficiency (CPHD) / dwarfism

Intervention

Sequence analysis and linkage analysis of the PROP1 gene

Outcome

Involvement of PROP1 gene in German shepherd dog dwarfism (CPHD)surrogate

The PROP1 gene is excluded as a candidate for combined pituitary hormone deficiency in German shepherd dogs, providing a new spontaneous model of hypopituitarism.

Cite This Study

Leeuwen et al. (2000) studied this question.

synapsesocial.com/papers/6a707bd82163a0a01bc4b2cc https://doi.org/10.1159/000015507

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Cloning, characterization, and physical mapping of the canine Prop-1 gene (PROP1): exclusion as a candidate for combined pituitary hormone deficiency in German shepherd dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cloning, characterization, and physical mapping of the canine Prop-1 gene (PROP1): exclusion as a candidate for combined pituitary hormone deficiency in German shepherd dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider