Key result
Co-administration of adriamycin with aliskiren and captopril significantly improved the dissipation of mitochondrial membrane potential and restored ATP levels in rat liver mitochondria.
Why the study?
Does inhibition of local Angiotensin-II with captopril and/or aliskiren prevent adriamycin-induced mitochondrial dysfunction and oxidative stress in the liver of rats?
Does inhibition of local Angiotensin-II with captopril and/or aliskiren prevent adriamycin-induced mitochondrial dysfunction and oxidative stress in the liver of rats?
Inhibition of local Angiotensin-II production with ACE and renin inhibitors attenuates adriamycin-induced oxidative stress and mitochondrial dysfunction in the liver of rats.
Warrants no clinical change in adriamycin use; leaves open translation of rat mitochondrial findings to human toxicity.
BACKGROUND: Adriamycin (ADR) is a drug used clinically for anticancer treatment; however, it causes adverse effects in the liver. The mechanism by which these adverse effects occur remains unclear, impeding efforts to enhance the therapeutic effects of ADR. Its hepatotoxicity might be related to increasing reactive oxygen species (ROS) and mitochondrial dysfunction. The interaction between ADR and the local renin-angiotensin system (RAS) in the liver is unclear. ADR might activate the RAS. Angiotensin-II (Ang-II) leads to ROS production and mitochondrial dysfunction. In the present study we investigated whether ADR's hepatotoxicity interacts with local RAS in causing oxidative stress resulting from mitochondrial dysfunction in the rat liver. MATERIAL/METHODS: Rats were divided into 5 groups: control, ADR, co-treated ADR with captopril, co-treated ADR with Aliskiren, and co-treated ADR with both captopril and Aliskiren. Mitochondria and cytosol were separated from the liver, then biochemical measurements were made from them. Mitochondrial membrane potential (MMP) and ATP levels were evaluated. RESULTS: ADR remarkably decreased MMP and ATP in liver mitochondria (p<0.05). Co-administration with ADR and Aliskiren and captopril improved the dissipation of MMP (p<0.05). The decreased ATP level was restored by treatment with inhibitors of ACE and renin. CONCLUSIONS: Angiotensin-II may contribute to hepatotoxicity of in the ADR via mitochondrial oxidative production, resulting in the attenuation of MMP and ATP production.
No takes yet. Share an insight, caveat, or question.
Taşkın et al. (2016) studied Adriamycin-induced hepatotoxicity (n=35). Captopril and Aliskiren vs. Adriamycin alone was evaluated on Mitochondrial membrane potential and ATP levels (p=<0.05). Co-administration of adriamycin with aliskiren and captopril significantly improved the dissipation of mitochondrial membrane potential and restored ATP levels in rat liver mitochondria.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: