An interpretable biological age

Biological age as an integrated value of biophysiological measures has been widely investigated as a biomarker of ageing. It outperforms chronological age in predicting the ageing pace since individuals with the same chronological age can vary in health.1 Until now, several biological age predictors have been developed (ie, second-generation biological age clocks), and most of them are based on clinical phenotypes, omics data (eg, epigenomics and transcriptomics), or both.2–5 The difference between predicted biological age and chronological age was defined as age acceleration, and individuals with positive age acceleration were thought to be ageing faster than those with the same chronological age.