The adsorption of radiotagged fibrinogen on modified polytetrafluoroethylene surfaces was measured to shed light on the reason of reduced thrombogenicity. These measurements show that when fibrinogen is adsorbed from a solution in which the molecules are in a coiled, undenatured state, adsorption is greater on sulfonated, etched Teflon—a reduced thrombogenic surface, than on unsulfonated, etched Teflon—a thrombogenic surface. On the other hand, when fibrinogen is picked up from a water‐air interface in the form of a monolayer consisting of denatured molecules, the pick‐up is independent of the thrombogenicity of the surface.
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Ziegler et al. (1970) studied this question.
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