December 31, 2014Circulation ResearchOpen Access

Deletion of GSK-3α specifically in cardiomyocytes attenuates ventricular remodeling and cardiac dysfunction after myocardial infarction, whereas specific deletion of GSK-3β in cardiac fibroblasts leads to fibrogenesis, left ventricular dysfunction, and excessive scarring.

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Population

Mouse models with cardiomyocyte- and fibroblast-specific conditional gene deletion of GSK-3

Design

Review

Authors

HLHind Lal FAFirdos Ahmad JWJames R. Woodgett

Discussion

Member takes

Overview

Cell-specific GSK-3 effects caution against nonselective inhibition post-MI; leaves open isoform-targeted strategies for prospective validation.

Structured PICO

Population

Mouse models with cardiomyocyte- and fibroblast-specific conditional gene deletion of GSK-3

Intervention

Deletion or inhibition of GSK-3 isoforms (GSK-3α and GSK-3β)

Outcome

Ventricular remodeling, cardiac dysfunction, myocardial fibrosis, and cardiomyocyte proliferation

GSK-3 isoforms have distinct and cell-specific roles in the heart, highlighting the complexity of targeting this pathway for myocardial diseases.

Cite This Study

Lal et al. (2014) studied this question.

synapsesocial.com/papers/6a707fa1ac440176ef2928ae https://doi.org/10.1161/circresaha.116.303613

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December 31, 2014Circulation ResearchOpen Access

Deletion of GSK-3α specifically in cardiomyocytes attenuates ventricular remodeling and cardiac dysfunction after myocardial infarction, whereas specific deletion of GSK-3β in cardiac fibroblasts leads to fibrogenesis, left ventricular dysfunction, and excessive scarring.

View Full Paper

Ask AI

Bookmark

Population

Mouse models with cardiomyocyte- and fibroblast-specific conditional gene deletion of GSK-3

Design

Review

Authors

HLHind Lal FAFirdos Ahmad JWJames R. Woodgett

Discussion

Member takes

Overview

Cell-specific GSK-3 effects caution against nonselective inhibition post-MI; leaves open isoform-targeted strategies for prospective validation.

Structured PICO

Population

Mouse models with cardiomyocyte- and fibroblast-specific conditional gene deletion of GSK-3

Intervention

Deletion or inhibition of GSK-3 isoforms (GSK-3α and GSK-3β)

Outcome

Ventricular remodeling, cardiac dysfunction, myocardial fibrosis, and cardiomyocyte proliferation

GSK-3 isoforms have distinct and cell-specific roles in the heart, highlighting the complexity of targeting this pathway for myocardial diseases.

Cite This Study

Lal et al. (2014) studied this question.

synapsesocial.com/papers/6a707fa1ac440176ef2928ae https://doi.org/10.1161/circresaha.116.303613

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