Exogenous hydrogen sulfide attenuates hyperoxia effects on neonatal mouse airways

Chronic airway disease is a short- and long-term consequence of premature birth. Understanding effects of O 2 exposure during the perinatal period is key to identify targetable mechanisms that initiate and sustain adverse airway changes. Our findings show a beneficial effect of exogenous H 2 S on developing mouse airway structure and function with notable sex differences. H 2 S donors alleviate effects of O 2 on airway hyperreactivity, contractility, airway smooth muscle thickness, and extracellular matrix deposition.