Ion Transport Unit, resistant to bronchodilators than that of chronic lations and thus suggesting some genetic National Heart and Lung Institute, obstructive pulmonary disease. 5 component to the disease.However, this as- Imperial College,The disease has been reported to be more sociation is yet to be confirmed.In addition, Manresa Road,prevalent in men and most have never smoked.a relatively small number of familial cases has London SW3 6LR, UK H KoyamaThe peak incidence occurs in the fifth and sixth been reported thus far, 20 though it is not undecades, 6 though it can occur at any age of usual that some of the siblings of the patients Department of adult life. 7 The titre of the cold haemagglutinin have chronic sinusitis without chest lesions. RespiratoryMedicine, Royal Brompton is raised in most patients, 8 and the changes in Based on a detailed observation of a single Hospital, the titre reflect the therapeutic response to case, Kudoh et al noticed that erythromycin Sydney Street, some extent.Other laboratory abnormalities might be effective in treating patients with DPB London SW3 6NP, UK include raised erythrocyte sedimentation rate, and performed an open trial which showed D M Geddes positive C reactive protein (CRP) and positive the beneficial effect of low dose, long term
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Koyama et al. (1997) studied this question.
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