In vivo real‐time imaging of nuclear‐cytoplasmic dynamics of dormancy, proliferation and death of cancer cells

The in vivo visualization of dormancy, proliferation, as well as cell death is of great importance in understanding the cellular pathology of cancer. We describe here the use of fluorescent proteins to differentially label cells in the nucleus and cytoplasm, and high-powered imaging technology to visualize the nuclear-cytoplasmic dynamics of these phenomena of cancer in vivo. The implications of this technology for discovery of new visible targets at the cellular level for treatment of cancer are discussed.