Why the study?
Does oral isosorbide reduce ventricular fluid pressure in hydrocephalic children?
Population
14 hydrocephalic children
Comparison
Oral isosorbide in doses varying from 1 to 3 gm… vs Baseline pressure pattern (intra-patient control)
Design
Case_series
Follow-up
72 hours
Authors
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Single-dose isosorbide may reduce ventricular pressure in hydrocephalic children; leaves open long-term safety and efficacy.
Does oral isosorbide reduce ventricular fluid pressure in hydrocephalic children?
Oral isosorbide effectively reduces ventricular fluid pressure in hydrocephalic children, though continuous administration beyond 72 hours leads to dehydration and hypernatremia.
Hayden et al. (1968) studied this question.
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