Renal Function and Electrolyte Metabolism in Acute Glomerulonephritis 1

Glomerular changes are perhaps the most out- standing anatomical lesions of acute glomerulonephritis. The glomerular tuft usually exhibits increased cellularity with deposits of fibrin or in- flammatory exudate in the capsular space. The capsule and basement membranes may become thickened but the arterioles and renal tubules appear relatively normal in the early phases of the disease. Several papers describe a characteristic functional pattern for acute glomerulonephritis which reflects the dominant glomerular lesion (14).