Enantiomeric resolution of (±)-etodolac by direct approach using both achiral phases in thin-layer chromatography: A conceptual approach

Direct enantioresolution of (±)-etodolac has been achieved by adopting a new conceptual approach involving both achiral phases in thin-layer chromatography (TLC). Enantiomerically pure l-tryptophan, l-phenyl alanine, l-histidine, and l-arginine were used as chiral inducing reagents (CIR); none of these was impregnated with silica gel (while making TLC plates) or mixed with the mobile phase. The solvent system MeCN—CH2Cl2—MeOH, in different proportions, was found to be successful for enantioresolution. Spots were located in iodine chamber. Effect of concentration of chiral inducing reagent and temperature on enantioresolution was studied.