Why the study?
Excessive adipose tissue accumulation and dysregulation of peri-organ adipose tissue are associated with metabolic disease, but the underlying mechanisms and potential treatment strategies require synthesis.
Key points are not available for this paper at this time.
Design
Review
Answers are grounded in this paper and cite their sources.
Peri-organ AT dysregulation is associated with metabolic complications; hypothesis-generating and requires prospective validation before clinical consideration.
Metabolic disease is a complex disorder defined by a group with interrelated factors. There is growing evidence that obesity can lead to a variety of metabolic diseases, including diabetes and cardiovascular disease. Excessive adipose tissue (AT) deposition and ectopic accumulation can lead to increased peri-organ AT thickness. Dysregulation of peri-organ (perivascular, perirenal, and epicardial) AT is strongly associated with metabolic disease and its complications. The mechanisms include secretion of cytokines, activation of immunocytes, infiltration of inflammatory cells, involvement of stromal cells, and abnormal miRNA expression. This review discusses the associations and mechanisms by which various types of peri-organ AT affect metabolic diseases while addressing it as a potential future treatment strategy.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2023) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: