Rejection of an HL—A Identical Renal Transplant

A 38‐year‐old man suffering from chronic glomerulonephritis received a kidney from his HL—A identical sister. The HL—A identity was fully established by tissue typing with well‐specified antisera and by mixed lymphocyte culture tests. One year after transplantation kidney function deteriorated, and repeated biopsies of the transplant, I 131 ‐Hippuran renography, and arteriography showed that the kidney was undergoing a chronic rejection. It is suggested that incompatibilities with regard to weak histocompatibility systems might have been responsible for the rejection of a human kidney.