Population
Heterologous cell expression system expressing Wild-type HCN4 or/and HCN4-G1097W
Comparison
Expression of HCN4-G1097W mutant channels vs Expression of Wild-type (WT) HCN4 channels
Design
Preclinical
Authors
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May link HCN4 variants to AV nodal dysfunction; leaves open human validation and therapeutic targeting.
The novel HCN4-G1097W mutation exerts a dominant-negative, loss-of-function effect on cardiac If channels, providing a genetic basis for AV nodal dysfunction.
Zhou et al. (2014) studied this question.
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