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Review
May aid clinician recognition of rare bleeding disorders; leaves open need for prospective validation of management strategies.
Excessive platelet activity is the cause of coronary artery syndromeswhere the obstruction of coronary arteries by platelet-rich thrombiformed in the vicinity of ruptured atherosclerotic plaques can lead tomyocardial infarction, the principal cause of death in the Westernworld. Identification of the molecular defects giving rise to bleedingsyndromes has been instrumental in defining the mechanismsunderlying haemostasis.The classic disorders of platelet adhesion and platelet aggregation areBernard–Soulier syndrome (BSS) (with giant platelets) and Glanzmannthrombasthenia (GT).
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Nurden et al. (2007) studied this question.
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