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Variant angina description leaves open its prevalence and management in contemporary practice; prospective studies needed before updating guidelines.
In 1959, Prinzmetal and colleagues described a new form of chest pain that developed at rest and very often occurred in the early morning hours.12 The pain was associated with ST segment elevations in the electrocardiogram and relieved by nitroglycerin. They named the syndrome "variant angina" and suggested that it was caused by a spasm of a major epicardial coronary artery.
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Thomas F. Lüscher (1991) studied this question.
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