Why the study?
Does dapagliflozin alter mitochondrial ATP synthesis, substrate oxidation rates, and ketone production in individuals with type 2 diabetes mellitus?
Population
18 individuals with type 2 diabetes mellitus (T2DM)
Comparison
Dapagliflozin for 2 weeks vs Placebo for 2 weeks
Design
RCT, randomized
Follow-up
2 weeks
Authors
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Dapagliflozin improves insulin sensitivity via substrate shift without altering mitochondrial ATP synthesis; extends mechanistic insights into SGLT2i effects.
Does dapagliflozin alter mitochondrial ATP synthesis, substrate oxidation rates, and ketone production in individuals with type 2 diabetes mellitus?
Dapagliflozin improves insulin sensitivity but shifts metabolism from glucose to lipid oxidation, providing a mechanistic explanation for increased ketone production and potential ketoacidosis risk in T2DM.
Daniele et al. (2016) studied this question.