Why the study?
The role of serotonin in arterial blood pressure regulation across states of vigilance is unknown.
CNS serotonin may be critical for preventing high arterial blood pressure in aging males.
CNS serotonin may buffer age-related ABP rises in males; leaves open translational relevance to human hypertension.
The role of serotonin in arterial blood pressure (ABP) regulation across states of vigilance is unknown. We hypothesized that adult rats devoid of CNS serotonin (TPH2-/-) have low ABP in wakefulness and NREM sleep, when serotonin neurons are active. However, TPH2-/- rats experience higher ABP than TPH2+/+ rats in wakefulness and REM only, a phenotype present only in older males and not females. CNS serotonin may be critical for preventing high ABP in males with aging.
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Magnusson et al. (2020) studied this question.
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