An evaluation of therapeutic surgical castration in the treatment of metastatic, recurrent, and primary inoperable mammary carcinoma in women. An analysis of 191 patients

that a significant and wide-I spread influence may be effected on mammary carcinoma by the production of hormonal imbalance.Oophorectomy immediately, totally, and effectively withdraws the gonadal secretion from circulation.The changes produced by castration may be clearly observed, although the mechanisms of production are not completely understood.It is our opinion that the results of this study will help to fmmulate a clearer rationale and indicate criteria for the selection of patients for extirpative endocrine therapy.We again repeat from a former report on this problem from the Breast Service of Memorial Center that: "Owing to the vagaries of the cancerous diseases and because of the human soil in which the cancer grows and as the result of many other factors, evaluation of castration will always remain out of the realm of exact scientific evaluation.On the other hand, one may obtain a general idea of the value of castration on purely clinical grounds."