Epidemiologically disparate strains of hepatitis A virus (HM-175 and PA-21) show a high degree of antigenic relatedness.
High antigenic relatedness of distinct HAV strains may support cross-protection; leaves open human vaccine implications.
Cell culture-adapted HM-175 (Australia) and PA-21 (Panama) strains of hepatitis A virus were compared in a cross-neutralization radioimmunofocus inhibition assay. The ratio of antibody titers achieved with two sera against the two viruses differed by less than twofold, indicating a high degree of antigenic relatedness between epidemiologically disparate strains of virus.
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Lemon et al. (1983) studied this question.
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