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February 1, 2022Annals of Medicine and SurgeryOpen Access

Global mortality of children after perioperative cardiac arrest: A systematic review, meta-analysis, and meta-regression

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Why the study?

Survival of children after perioperative cardiac arrest and its independent predictors remain uncertain and debated globally.

Design

Systematic review and meta-analysis of observational studies

Authors

SASemagn Mekonnen AbateSNSolomon NegaBBBivash Basu

Discussion

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Overview

Pooled pediatric perioperative arrest mortality estimates highlight ongoing risk; leaves open questions on modifiable predictors and targeted interventions.

Structured PICO

P
Population
3.35 million children (pediatrics) receiving any form of anesthetics across 38 observational studies globally.
I
Intervention
Perioperative anesthesia (any form)
O
Outcome
Incidence of perioperative cardiac arrest and anesthesia-related mortalityhard clinical

The incidence of perioperative cardiac arrest and mortality in children remains persistently high, particularly in low- and middle-income countries, highlighting a critical need for improved pediatric anesthesia safety and training.

Limitations

  • Substantial heterogeneity between the included studies
  • Majority of included studies didn't report the mean or median age of the study participants
  • Publication bias detected (trim fill showed three studies were missed)

Cite This Study

Abate et al. (2022) studied this question.

synapsesocial.com/papers/6a708fbc660549caf2c52ae4https://doi.org/10.1016/j.amsu.2022.103285
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