Therapeutic Radiometals Beyond ¹⁷⁷Lu and ⁹⁰Y: Production and Application of Promising α-Particle, β⁻-Particle, and Auger Electron Emitters

In recent years, new α-particle–, β⁻-particle–, and Auger electron–emitting radiometals—such as ⁶⁷Cu, ⁴⁷Sc, ¹⁶⁶Ho, ¹⁶¹Tb, ¹⁴⁹Tb, ²¹²Pb/²¹²Bi, ²²⁵Ac, and ²¹³Bi—have been produced and evaluated (pre)clinically for therapeutic purposes. In this short review article, the most important routes of production of these radiometals are critically discussed, as are examples of their application in preclinical and clinical studies.