The latest strategies in the design and synthesis of metal‐organic frameworks as heterogeneous catalysts in organic synthesis are compared with biocatalyzed transformations, as a step forward to a more convenient industrial production of pharmaceuticals. Relevant C−C and C−N bond forming reactions that are both chemo‐ and bio‐ catalyzed by synthetic MOFs and in vitro evolved and/or promiscuous enzymes with the aim of obtaining key bioactive scaffolds in a sustainable, competitive and cost‐efficient manner, are thoroughly discussed in this mini review.
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Francisco G. Cirujano (2019) studied this question.
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